Proteus
Expression and Production of Proteins—Service and Research
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Proteos is a flexible resource for our customers. We can follow your protocols and use your cell lines, cDNAs, purification methods, etc. for carrying out a contract, and thus provide a Service leading to a product that is at a specified state of purity. Proteos scientists come from a background in the pharmaceutical industry where they were always called upon to solve problems. Often our clients require input from Proteos in the way of a Research effort to solve one or more problems along the production train, both in expression and purification. For example, if scale-up expression and production is required but the customer has had difficulties with a bacterial expression system due to inclusion body formation, they may well avoid the prospect of trying to refold the protein to an active form. Proteos has special skills in protein refolding, and may explore application of our proprietary folding method, which is both elegant and cost-effective. We may also change the cDNA to optimize needed levels of expression. In the same vein, many customers have not been able to achieve the level of purity required for their target protein and here is where the long expertise of our scientists can be brought to bear to develop protocols that work.
Protein crystallographers in large pharma, biotech companies, and academic institutions comprise a major customer base for Proteos. They look to us to provide the especially high purity proteins required for x-ray crystallography. Our track record of producing crystallographic grade protein is well documented for proteins from a diverse set of families and Proteos has provided highly purified protein to customers throughout the world. Proteos has a strategic alliance with an academic crystallographer who can provide screening a wide variety of conditions to identify those that support crystal growth for the target protein.